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KMID : 1035620230110020077
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Allergy Asthma & Respiratory Disease
2023 Volume.11 No. 2 p.77 ~ p.81
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Current practice of antibiotics skin test in pediatric inpatients: A single-center experience
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Roh Yun-Young
Kim Ha-Min
Park Mi-Reu
Kim Soo-Yeon
Kim Jong-Deok
Kim Min-Jung
Lee Yong-Ju
Kim Yoon-Hee
Kim Kyung-Won
Sohn Myung-Hyun
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Abstract
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Background: Routine practice of antibiotic skin test (AST) before administering antibiotics is with little scientific basis. However, AST is frequently performed in real-world practice. We aimed to explore the current practice status of AST.
Methods: All admission cases in Severance Hospital between January 2019 and December 2020 of patients at less than 19 years of age were collected retrospectively. AST results for 4 penicillins (ampicillin, ampicillin-sulbactam, amoxicillin-clavulanate, and piperacillin-tazobactam) and 6 cephalosporins (cefazolin, cefotaxime, cefotiam, cefpiramide, ceftriaxone, and flomoxef) as well as adverse drug reaction (ADR) reports were collected.
Results: Among 36,381 hospitalization cases, 7,589 and 16,468 were administered penicillins and cephalosporins, respectively. Penicillins were administered without AST in 2,622 cases (35%), 2 (0.08%) of which showed ADR. Of the remaining 4,967 cases who received AST, 57 (1.1%) showed a positive reaction. For cephalosporins, 15,473 cases (94%) received antibiotics without AST. Among them, 17 cases (0.1%) showed ADRs. For 995 cases that rceived AST, 22 (2.2%) revealed a positive reaction. Among 79 cases who were AST positive, 10 took the original medication.
Conclusion: The current practice of AST reveals heterogeneous and inconsistent patterns. This brings the need for a standardized guideline for the safe and effective use of antibiotics.
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KEYWORD
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Skin tests, Penicillins, Cephalosporins
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